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10 Best Cannabis Strains for Migraines

By Zen Leaf Team April 7, 2025
420 celebrations with cannabis

Migraines can stop you in your tracks—whether you're at work, relaxing at home, or trying to sleep. For many, traditional treatments fall short, leaving them searching for alternative ways to find relief. That’s where cannabis may come in. From high-CBD strains to soothing indicas, the plant offers promising options for easing migraine symptoms. Let’s break down what you need to know and explore which strains may help you feel better, faster.

What are Migraines?

Migraines are more than just a headache—they're a neurological condition that can bring on intense, throbbing pain often accompanied by nausea, sensitivity to light and sound, and even visual disturbances. These episodes can last anywhere from a few hours to several days, disrupting daily life and wellbeing.

Can Cannabis Help Manage Migraines?

Cannabis has shown promise in helping manage migraine symptoms thanks to its anti-inflammatory, analgesic, and anti-nausea properties. Both THC and CBD may help reduce the intensity and frequency of migraines by interacting with the body’s endocannabinoid system, which plays a role in pain regulation. Some patients report fewer migraine attacks and faster relief when using certain cannabis strains.

Top 10 Strains to Try for Migraines

If you're seeking relief, these strains may help soothe your symptoms:

Ringo’s Gift

This CBD-dominant strain delivers calming relief with minimal psychoactive effects, making it a favorite for daytime migraine support.

Cannatonic

Known for its gentle high and high CBD content, Cannatonic is ideal for patients seeking balance and soothing pain relief without feeling foggy.

Northern Lights

A powerful indica that promotes full-body relaxation—perfect for shutting down migraine symptoms and easing into rest.

Sour Tsunami

One of the pioneering high-CBD strains, Sour Tsunami is valued for its anti-inflammatory effects and ability to calm nausea.

LA Confidential

This potent indica has sedative properties that help reduce stress, calm the senses, and make migraine downtime more bearable.

Pennywise

With its 1:1 CBD to THC ratio, Pennywise offers gentle cerebral effects alongside physical relief—ideal for staying functional.

Zkittlez

A flavorful indica that helps with sensory overload while promoting calmness, which can be key during migraine episodes.

Skywalker OG

Heavy-hitting and deeply relaxing, Skywalker OG may help with migraines linked to tension and stress.

Jack Herer

An energizing sativa that provides mental clarity and mild euphoria while still delivering anti-inflammatory effects.

Cherry Wine

A mellow, CBD-rich strain that’s often used for daily symptom management and to ward off migraine onset.

What to Look for When Choosing Strains for Migraines

Not all cannabis strains are created equal when it comes to migraine relief. Here are some key traits to look for:

  • High-CBD or Balanced CBD/THC Ratios: These often reduce pain without intense psychoactive effects.
  • Terpenes like Myrcene, Linalool, and Caryophyllene: Known for their calming and anti-inflammatory benefits.
  • Indica or Indica-Dominant Hybrids: These strains may be more effective for pain and sleep support.

Things to Consider When Managing Migraines With Cannabis

Managing migraines with cannabis should be a thoughtful process:

  • Track Your Triggers: Keep a journal to identify foods, stress, or sleep patterns linked to your migraines.
  • Start Low and Go Slow: Especially important for new patients or those trying new strains.
  • Talk to a Medical Professional: Especially if you’re using cannabis as part of a broader treatment plan.
  • Try Different Formats: Tinctures, vapes, edibles, and flower each offer unique onset times and durations.

Where to Find the Best Strains for Migraines

Looking for relief? Zen Leaf carries a wide range of cannabis products to help patients and consumers manage migraines. Whether you're seeking CBD-rich strains or relaxing indicas, our knowledgeable staff can guide you to the right fit. Visit your nearest Zen Leaf dispensary or browse online to explore migraine-friendly options.

Our team of authors is not just a group of writers; they are dedicated cannabis experts and pharmacists with years of experience in the industry. Each member brings a unique perspective, combined with a deep understanding of cannabis' therapeutic benefits, emerging research, and regulatory landscape.

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